England striker Daniel Sturridge will take no part in Tuesday's World Cup qualifier in Ukraine because of injury.
A statement on the FA website read: "Club England medical staff have been in constant contact with their counterparts at Liverpool Football Club since he returned there on Thursday.
"His injury has not progressed as had been hoped and it is now clear that Sturridge will not be fit for the match in Kiev on Tuesday evening."
Although the news will not be a surprise to Roy Hodgson, the manager would have been quietly hoping the on-song forward would recover after aggravating a groin injury in Liverpool's triumph over Manchester United last weekend.
The 24-year-old also missed England's 4-0 win on Friday night against Moldova, but injuries to Manchester United's Wayne Rooney and West Ham's Andy Carroll, plus the suspension of Danny Welbeck, leaves England with a selection headache.
Hodgson has already been making plans for their crucial trip to Ukraine and seems set to start with Manchester City midfielder James Milner by stating: "We are going to need experience in Kiev. Milner is not a winger, but the qualities he brings could be very useful."
It was also confirmed that England will not be drafting in any replacements to his squad of 23 who travel to Kiev on Sunday evening.
With England leading Group H, the pressure is on Ukraine to go for the spoils, but they will be confident of upsetting the visitors having smashed nine goals past San Marino on Friday.
