A Champions League tie played in England is one of 380 matches across Europe investigators say was fixed.
European police did not reveal the identity of the match they believe was corrupt in England.
But Europol did say that they had uncovered an organised crime syndicate based in Asia that was co-ordinating the operation.
Some 425 match officials, club officials, players and criminals are suspected of being involved.
At a news conference in The Hague, Netherlands, Europol claimed:
The fixed Champions League tie in England took place in "last three or four years";
The identity of that match cannot be revealed due to "ongoing judicial proceedings";
Other "corrupt" matches included World Cup and European Championship qualifiers and "several top football matches in European leagues";
In Germany-based matches alone, criminals wagered £13.8m (16m euros) on rigged matches and made £6.9m in profits
Officials fear this is as the "tip of the iceberg".
Rob Wainwright, director of Europol - the European Union's law enforcement agency, said:"This is the work of a suspected organised crime syndicate based in Asia and operated with criminal networks around Europe.
"It is clear to us this is the biggest-ever investigation into suspected match-fixing in Europe. It has yielded major results which we think have uncovered a big problem for the integrity of football in Europe.
Who do you suspect it is?
